USB memory sticks have a finite lifespan (measured in reads & writes).
With a modern stick, you are probably not going to hit it for a long
time. I would however suggest that you have some backup scheme to back
the file up to a hard drive regularly, and with increasing frequency the
older the stick becomes.
I don't know of anyone actually having tried this, so you are in
uncharted territory.
Do you want to do this so that you are able to transport the PST or in
an attempt to increase performance?

Patrick Schmid [OneNote MVP]
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http://pschmid.net
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"Gordon" wrote in message
:

Are there any known pitfalls in having my pst file on a USB memory stick?