John Lenz wrote:

How do you change the reply-to address of an eMail that originates in
outlook 2003 as the client to an exchange server. If outlook was a
client to an MAPI ISP, there is a reply-to address in the profile.

Where do I set the reply-to address as an outlook-exchange client?

You set it in Active Directory.
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Brian Tillman [MVP-Outlook]